Cholestyramine (a.k.a. brand name Questran), colesevelam (a.k.a. brand name Welchol), and colestipol (a.k.a. brand name Colestid), are medications that are classified as a bile acid sequestrant. The medications work by binding to bile acids in the intestines, thereby reducing the reabsorption of bile acids and promoting the elimination of cholesterol and toxins from the body.
Key points:
Uses: These are prescribed to individuals with high cholesterol, specifically high levels of low-density lipoprotein (LDL) cholesterol.
Administration: These are generally taken with meals to maximize its cholesterol-lowering effects. To prevent interactions, take other medications at least one hour before or four to six hours after taking colesevelam.
Side Effects: Common side effects may include constipation, stomach discomfort, gas, and nausea. Colesevelam may interfere with the absorption of certain fat-soluble vitamins (A, D, E, K) and of certain medications.
Contraindications: These should not be used in individuals with a history of bowel obstructions or certain gastrointestinal disorders.
Duration of Use: These are generally used as a long-term treatment. The duration of use is determined by a healthcare provider based on individual needs and response to treatment.