Interleukin-6 (IL-6) is a cytokine, which is a type of signaling molecule that plays a crucial role in the regulation of the immune system and inflammation. IL-6 is produced by various cells, including immune cells, fibroblasts, and endothelial cells, and it has diverse functions in the body.
Key points:
Inflammatory Response: IL-6 is a pro-inflammatory cytokine, meaning it is involved in promoting inflammation. It is released in response to infections, tissue injuries, and other inflammatory stimuli.
Acute Phase Response: IL-6 is a key mediator of the acute phase response, which is the body’s immediate and early response to inflammation. It stimulates the liver to produce proteins involved in inflammation, tissue repair, and the immune response.
Chronic Inflammation: Elevated levels of IL-6 are associated with chronic inflammatory conditions. In these conditions, IL-6 contributes to persistent inflammation and tissue damage.
Cardiovascular Health: Elevated levels of IL-6 are associated with an increased risk of cardiovascular events.
Role in Cancer: IL-6 is involved in the regulation of cell growth and survival. In some cases, elevated levels of IL-6 are observed in cancer, and it may contribute to tumor progression.
Therapeutic Target: Due to its involvement in inflammation and various diseases, IL-6 has become a therapeutic target for certain conditions. Monoclonal antibodies targeting IL-6 or its receptor are used in the treatment of autoimmune diseases.
Testing: IL-6 levels can be measured through blood tests. Elevated levels may indicate inflammation or certain medical conditions.