Mast Cell Activation Syndrome (MCAS): differential diagnoses

• diabetes mellitus
• porphyria
• sarcoidosis
• thyroid disorders
• Fabry disease
• Helicobacter pylori gastritis
• infectious/inflammatory bowel/skin/genitourinary diseases
• celiac disease
• lactose/sucrose/fructose intolerance
• amyloidosis
• intestinal adhesions/volvulus/obstruction
• hepatitis, cholecystitis
• median arcuate ligament syndrome
• neuroendocrine cancers (carcinoid, pheochromocytoma, etc.)
• pancreatic endocrine tumors
• food/environmental/chemical allergy
• asthma
• allergic rhinitis
• eosinophilic esophagitis/enteritis
• hypereosinophilic and hyper-IgE syndromes
• immunodeficiencies
• autoinflammatory syndromes
• hereditary angioedema
• vasculitis
• hypermobility syndromes
• lymphoma
• myeloproliferative neoplasms
• mental health diagnoses, such autism, anxiety/panic, depression, psychosomatism, conversion disorder, Munchausen’s syndrome.