Mast Cell Activation Syndrome (MCAS) treatments can use medications such as:
Antihistamines: Non-sedating, second-generation antihistamines like cetirizine (Zyrtec), loratadine (Claritin), or fexofenadine (Allegra) are commonly used to block the effects of histamine and manage symptoms such as itching, flushing, and hives.
Mast Cell Stabilizers: Medications like cromolyn sodium (Gastrocrom) or ketotifen (Zaditor) can help stabilize mast cells and reduce their reactivity.
Leukotriene Modifiers: Montelukast (Singulair) is a leukotriene receptor antagonist that may be prescribed to manage respiratory and other symptoms.
Proton Pump Inhibitors (PPIs): PPIs like omeprazole (Prilosec) can help manage gastrointestinal symptoms by reducing stomach acid production.
Adrenaline Auto-Injector: Individuals with MCAS who are at risk of severe allergic reactions, including anaphylaxis, may be prescribed an adrenaline (a.k.a. epinephrine) auto-injector and trained on how to use it in case of an emergency.
Mast Cell Stabilizing Medications: In more severe cases of MCAS, medications like tyrosine kinase inhibitors (e.g., imatinib) or anti-IgE therapy (e.g., omalizumab) may be considered to manage symptoms and mast cell activation.