Mast Cell Activation Syndrome (MCAS) is a complex and variable condition where mast cells, a type of immune cell, are hyperactive and release excessive amounts of various chemical mediators. Symptoms and severity can vary widely among individuals with MCAS.
While there isn’t a standardized severity classification for MCAS, healthcare providers often assess the condition based on the frequency and severity of symptoms, as well as their impact on an individual’s quality of life.
Severity levels:
Mild MCAS: Individuals with mild MCAS may experience intermittent symptoms, which are generally well-controlled with antihistamines or other medications. Symptoms may be bothersome but not severely limiting daily activities.
Moderate MCAS: Those with moderate MCAS may have more frequent or persistent symptoms that require ongoing medication management. Symptoms can affect daily life and may lead to some restrictions in activities.
Severe MCAS: Severe MCAS is characterized by frequent, severe, and debilitating symptoms that may significantly impair an individual’s ability to function. Daily life can be greatly impacted, and these individuals often require aggressive and continuous treatment, including high-dose medications and lifestyle modifications.